chantix memory loss side effects


Weight loss is a frequent complication of Alzheimer disease (AD), associated with increased morbidity and mortality. If experienced, these tend to have a Less Severe expression 1. Took the chantix for a total of 30 days. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, does not establish causal relationship, and has not been supported by scientific studies or clinical trials unless otherwise stated. The most common side effects of CHANTIX include nausea (30%), sleep problems (trouble sleeping, vivid, unusual, or strange dreams), constipation, gas and/or vomiting. This phase IV clinical study is created by eHealthMe based on reports of 936 people who have side effects when taking Chantix from sources other than the FDA, and is updated regularly. Summary: We study how severe was Memory loss, when it was recovered, drug effectiveness, race, and more among people who take Chantix. It is possible that the side effects that you experienced can be attributed to the Chantix (Varenicline). A. Chantix (varenicline) is a relatively new oral prescription medicine to … Will you have Restless Leg Syndrome with Elavil? Mar 11, 2015 - Chantix, a smoking-cessation drug made by Pfizer, Inc., may cause seizures, according to a report by the U.S. Food and Drug Administration (FDA). What is CHANTIX? Talk to your doctor if you think a medication may be contributing to your memory loss. The rate of side effects is controversial. Some of these skin reactions can become life-threatening Will you have Urinary Tract Infection with Solu-Medrol? Chantix, the brand name for the prescription drug varenicline, is used to help people stop smoking. All rights reserved. Does metformin cause memory loss? Side effects of Zyban that are different from Chantix include agitation, dizziness, tremor, weight loss or gain, changes in appetite, ringing in your ears, loss of interest in sex, sore throat, muscle pain, itching or skin rash, increased sweating, and increased urination. In 2011, multiple studies were done in order to conclude that the benefits associated with Chantix were indeed greater than any of the risks. Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. Chantix has active ingredients of varenicline tartrate. Chantix treatment has been associated with weight gain. Among them, 4 people (0.43%) have Memory loss. The manufacturer of the anti-smoking drug, Pfizer, has agreed to … ! That is stated in the prescribing information, which also says that depression and anxiety are frequent side effects. The results are expected in 2017. Although not all of these side effects may occur, if they do occur they may need medical attention. Any person experiencing sudden, sharp and sustained chest pain should seek immediate medical attention. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. * Approximation only. loss in sexual ability, desire, drive, or performance. It is recommended that patients use the information presented as a part of a broader decision-making process. Again, the most common ones are the least serious and are likely to be temporary. Common drugs people take besides Chantix *: Common side effects people have besides Memory loss *: Check whether Memory loss is caused by a drug or a condition. Sources reveal that intake of the quit smoking aid medication chantix is likely to make you a victim of many side effects and weight gain is one of them. Check with your doctor immediately if any of the following side effects occur: More common. redness in the joints. But Chantix isn’t for everyone. An FDA panel ruled on July 1, 2009, that Chantix and Zyban should carry "black box" warnings, highlighting the … Its unique mechanism of action among antidepressants may be due to the reuptake of norepinephrine (a chemical in the brain and body that functions as a neurotransmitter and hormone) and dopamine. Common side effects include constipation, dizziness, increased sweating, lightheadedness, loss of appetite, nausea, vomiting, and weakness. Duane Graveline, a former astronaut, reported coming back from a short walk and … F: 39 8 days: 1X D 12/28/2020: 1: Quit smoking An objective causality assessment indicated a possible relationship between the memory loss and … Find everything you need to know about Chantix (Varenicline), including what it is used for, warnings, reviews, side effects, and interactions. Case summary: An 87-year-old white woman was started on fluoxetine for depression, and the dose was titrated to 20 mg/d. Patients may experience psychiatric symptoms such as behavioral changes, agitation, depressed mood, and suicidal behavior while using Chantix. The following are common side effects of Chantix therapy with the percentage of users who experience them. SIDE EFFECTS FOR CHANTIX: COMMENTS: SEX: AGE: DURATION/ DOSAGE: DATE ADDED : 1 : Nausea, abdominal pain, vivid dreams, swelling in my hands legs, sever pain in muscles specially my calfs !! Throwing Up © 2021 eHealthMe.com. Side Effects of Adderall. In this article, our pharmacist discusses whether or not metformin causes memory loss and how to reverse the effects. It is based on varenicline tartrate (the active ingredients of Chantix) and Chantix (the brand name). Oct 31, 2017. eHealthMe is studying from 85,932 Chantix users. You are now leaving CHANTIX.com to enter a website neither owned nor operated by Pfizer. Real Health News from Medicine's Most Notorious Myth-Buster Irritability, loss of taste/smell, loss of memory. It both reduces craving for and decreases the pleasurable effects of cigarettes and other tobacco products.. any suggestions. Answered By: Dr. Brian Staiger Pharm.D. So basically, lots of psychological effects. Side effects: insomnia, weird dreams, but not too bad. In studies, decreased sex drive (also known as libido) was one of the infrequent Chantix side effects, although the exact percentage of people who developed this problem was not reported.Usually, when side effects are reported as "infrequent," it means that they occurred in between 1 in 100 and 1 in 1,000 people taking the medication. Some of these allergic reactions can be life-threatening Serious skin reactions, including rash, swelling, redness, and peeling of the skin. Since Chantix was released in 2006, thousands of smokers have been freed from their nicotine addiction and are now living free of cigarettes for the first time in years - … Find patient medical information for Chantix Starting Month Box oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Different individuals may respond to medication in different ways. Chantix side effects that she wont believe me. redness of the face, neck, arms and occasionally, upper chest. Allergic reactions can happen with CHANTIX. Drug information provided by: IBM Micromedex. Being forgetful changes in patterns and … hearing loss. The most common side effects of CHANTIX include nausea (30%), sleep problems (trouble sleeping, vivid, unusual, or strange dreams), constipation, gas and/or vomiting. It both reduces craving for and decreases the pleasurable effects of cigarettes and other tobacco products. She claimed he had had bizarre hallucinations that worsened when he … Vomiting and dizziness or vertigo can also be side effects seen in other conditions such as migraines or uneven pressure in the middle ear. Will you have Urinary Tract Infection with Solu-Medrol? For years, there has been conflicting evidence on whether or not metformin… Could not handle wanting to kill or the itchy/prickly skin. Check in with your doctor about any side effects you're experiencing with Wellbutrin if they're severe, bothersome, get worse, or don't go away. Pfizer also noted that at the FDA's request, the company is conducting a clinical trial to study the link between Chantix and psychological side effects. ...my friend is taking Chantix and I have noticed some really bad changes in her personality. The rare side effects include seizures, behavioral changes, difficulty in breathing, hyperventilation, tightness in the chest, suicidal thoughts, fever, cough, chills, itching or skin rash, loss of appetite, sneezing, sore throat, stuffy nose, loss of voice, and hallucination. If you have side effects that bother you or don’t go away, tell your healthcare provider. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Leave a Reply Cancel reply. Although older adults make up only 15 percent of the U.S. population, they receive more than 30 percent of all prescriptions written in this country. inability to have or keep an erection. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. It is recommended that patients use the information presented as a part of a broader decision-making process. Biohazard Bag Definition. loss of voice. For example, the kidneys may not remove drugs from the bloodstream … It is a high-affinity partial agonist for the α4β2 nicotinic acetylcholine receptor subtype (nACh) that leads to the release of dopamine in the nucleus accumbens when … We study how severe was Memory loss, when it was recovered, drug effectiveness, race, and more among people who take Chantix. Side effects that I experienced – Trouble falling asleep, trouble staying asleep, extremely vivid dreams, Lots of sleep issues in general, short term memory loss that persisted for a month after I stopped taking chantix, and seeing things that weren’t real. My mother in law went on the chantix program. 936 people reported to have side effects when taking Chantix. Overall lethargy flu symptoms: Don't take this toxic drug..you will harm urself more than you benefit ... this is crazy !!!! The pill is nicotine-free, which is a marked difference from some smoking cessation products on the market, and it allows smokers to keep smoking for the first week of their treatment. burning feeling in feet/toes, or. Memory loss also can be a side effect of other medicines, such as steroids, anti-depressants, sleeping pills, and pain medications. Whether this is linked to the treatment of ADHD with Adderall or simply ADHD itself has yet to be determined. Objective: To report a case of severe memory loss in an elderly patient after initiation of fluoxetine. http://www.whitneyowen.com - What Are The Side Effects Of Chantix - My Experience On January 1st, 2015 I quit smoking with chantix. AskDocWeb: It is not a normal side effect of Chantix but swelling of the hands, feet and lower legs may indicate a cardiovascular side effect. Dosage of drugs is not considered in the study. A couple of sources also highlight that people taking the anti smoking drug chantix gain an average body weight of 2.37 kg. Increased appetite and weight gain are known side effects … our memory clinic for … Post navigation. Varenicline (trade name Chantix and Champix) is a prescription medication used to treat nicotine addiction. Taking Chantix to quit smoking; just started the higher dose pills yesterday and am having bad stomach cramps and … The long and substantial clinical trials undertaken by the medical scientists at Pfizer have proved that Chantix is indicated for the treatment of adults to quit smoking. All information is observation-only, does not establish causal relationship, and has not been supported by scientific studies or clinical trials unless otherwise stated. unusual pain in the legs when walking. Running one of the largest drug safety studies in the world, eHealthMe is able to enable everyone to run personal clinical trial. Despite the possible bad Chantix side effects, the benefits of using Chantix massively outweigh the bad or potential negative reactions to the medication. Some reports may have incomplete information. 83,911 people reported to have side effects when taking Chantix. Advertisement . Native Hawaiians/Pacific Islanders: 0.0 %. Answered by : Dr. Sunil Gupta ( Psychiatrist) How to cope up with Chantix side effects? Chronic Trouble Sleeping 3. Chantix (varenicline) is an anti-smoking drug associated with serious side effects. It is created by eHealthMe based on reports of 83,911 people who have side effects when taking Chantix from the FDA, and is updated regularly. Start now, it's free and anonymous. The pill is nicotine-free, which is a marked difference from some smoking cessation products on the market, and it allows smokers to keep smoking for the first week of their treatment. redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid She developed progressive memory loss over the next 6 weeks for which she ultimately was hospitalized. Get help right away if you have any side effects that could be serious or life-threatening. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. After fluoxetine was discontinued, the patient's memory improved significantly over the next 2 months. This phase IV clinical study is created by eHealthMe based on reports of 936 people who have side effects when taking Chantix from sources other than the FDA, and is updated regularly. She developed progressive memory loss over the next 6 weeks for which she ultimately was hospitalized. See below for a comprehensive list of adverse effects. First, it partially activates sites in the brain, known as nicotinic acetylcholine receptors, that are affected by nicotine. increased appetite. Other drugs that have the same active ingredients (e.g. Common Chantix side effects may include: nausea (may persist for several months), vomiting; constipation, gas; sleep problems ( insomnia ); or unusual dreams. Going off Mirapex seemed to get rid of the problem. In 2009, the FDA began requiring a … increased urge to urinate during the night. The prescription medication can help with smoking cessation. Wingo asked. I have trouble remembering things I used to do on a daily basis. A number of individuals throughout the Unit It is often used in quit smoking. I feel as though the longer I have been on the drug, I have gotten worse. Memory loss and drugs with ingredients of varenicline tartrate. I tell everyone thinking about taking Chantix to make sure they talk to the doctor about ALL of the possible side effects. Gas 6. Recent studies on the possibility of these kinds of side effects were discussed at an FDA Advisory Committee meeting in October 2014. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. I have stupidly taken chantix 3 separate times, each with varying degrees of all their reported side effects. It is the brand name of a drug called bupropion that belongs to the family of drugs known as antidepressants. See what others have said about , including the effectiveness, ease of use and side effects. Gave up the chantix three weeks ago...just tapered down on my own, w/doctor's approval. A study published by the National Center for Biotechnology Information found that those with ADHD had a significantly higher chance of developing dementia than those without. Chantix, the brand name for the prescription drug varenicline, is used to help people stop smoking. Answer . Chantix is a prescription medication designed to help smokers quit the habit. The prescription medication can help with smoking cessation. (latest outcomes from Valium 37,093 users) memory loss. Albrecht had started taking Chantix with his fiancée, with seemingly dramatic side effects. Varenicline (trade name Chantix and Champix) is a prescription medication used to treat nicotine addiction. Chantix, also known as Varenicline, is a medication that is highly effective at reducing nicotine cravings. * Approximation only. I have been off Chantix for 2 weeks tomorrow and I called Pfizer to ask them how long the side effects will last, they have no idea!! Memory loss is found among people who take Chantix, especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months. Other drugs that have the same active ingredients (e.g. I agree that some of the effects I have are related to my quit, but the memory loss and iratic behavior I believe is due to the drug. If your memory loss is a side effect of breast cancer treatment, try the following tips to help stimulate your memory: … This gives new ex-smokers mild nicotine-like effects and eases symptoms of nicotine withdrawal. Other side effects may be discussed with a physician for possible symptom management. Side Effects. While Chantix was once thought to be the next great blockbuster medication for Pfizer, sales have plummeted on concerns that it increases the risk of suicide, suicide attempts, unusual behavior, and possibly even diabetes. According to Pfizer’s third-quarter earnings statement, Chantix side effects have clearly had an impact on doctors’ and patients’ use of the drug. ... Side Effects What are the side effects of Chantix ... You may report side effects to FDA at 1 … All rights reserved. In rare instances, suicidal ideation and psychotic episodes may happen. She was a smoker of over 50 years. Chantix is a prescription medication designed to help smokers quit the habit. It’s important to keep an eye on the side effects you experience because, as she says, it’s possible that these symptoms could be a result of COVID-19. insomnia (37%) nausea (30%) abnormal … However, this time after returning to smoking, I … Some patients reported short-term memory loss, such as not remembering what they did the day before. Some reports may have incomplete information. Side effects of Chantix, a popular stop smoking drug, have been linked to an increased risk of suicides, suicide attempts, aggressive and unusual behavior. By day 13 I went down to one pill a day. Unfortunately, as people age, natural changes within the body make adverse effects from medications more likely. The phase IV clinical study analyzes which people take Chantix and have Memory loss. Will you have Sciatica with Bronchitis Chronic? The phase IV trial will monitor drug safety outcomes that are personalized to your gender and age (0-99+). Awesome job on … Memory loss is found among people who take Chantix, especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months. Your email address … Different individuals may respond to medication in different ways. Memory loss is found to be related to 3,539 drugs and 3,564 conditions by eHealthMe. The use of the eHealthMe site and its content is at your own risk. Chantix works on two levels. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. There have only been studies to confirm short-term memory problems … Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Chantix is not addictive and is not a controlled substance; however, some patients may experience irritability and sleep … Zyban. Will you have Sciatica with Bronchitis Chronic? The study uses data from the FDA. The Internet Marketing Company. The phase IV clinical study is created by eHealthMe based on reports of 83,911 people who have side effects when taking Chantix from the FDA, and is … As a result, major side effects can include memory loss, confusion, delusions, hallucinations, drowsiness and compulsive behaviors such … Please see full Prescribing … Pfizer accepts no responsibility or liability for the … Behavioral Considerations. Mild nausea the first week. Feel Like Throwing Up 5. Will you have Deafness Unilateral with Diltiazem Hydrochloride? Chantix Side-effects. It works in the brain to lessen craving, nicotine withdrawal, and satisfaction from smoking. Learn more about Chantix … I do totally agree that Chantix got me where I needed to be with quiting and believe me I will be extremely careful moving forward and will not even allow myself a puff ever again in fear I will be right back to a pack a day. Insomnia (sleeplessness): 444 people, 17.67%, Nausea (feeling of having an urge to vomit): 408 people, 16.24%, Fatigue (feeling of tiredness): 365 people, 14.52%, Disturbance In Attention: 329 people, 13.09%, Headache (pain in head): 324 people, 12.89%, Mood Swings (an extreme or rapid change in mood): 292 people, 11.62%, Agitation (state of anxiety or nervous excitement): 263 people, 10.47%, Hallucinations (sensations that appear real but are created by your mind): 240 people, 9.55%, Malaise (a feeling of general discomfort or uneasiness): 224 people, 8.91%, Loss Of Consciousness: 217 people, 8.64%, Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 213 people, 8.48%, Nightmares (unpleasant dreams): 184 people, 7.32%, Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 161 people, 6.41%, Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 152 people, 6.05%, Mental Impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 131 people, 5.21%, Tremor (trembling or shaking movements in one or more parts of your body): 119 people, 4.74%, High Blood Cholesterol: 208 people, 8.28%, Insomnia (sleeplessness): 59 people, 2.35%, Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 56 people, 2.23%, Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 56 people, 2.23%, Bipolar Disorder (mood disorder): 51 people, 2.03%, Arthritis (form of joint disorder that involves inflammation of one or more joints): 49 people, 1.95%, Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. chest pain; fast, slow, or irregular heartbeat; memory loss; mental or mood changes (eg, agitation, depression); seizures; severe or persistent nausea; suicidal thoughts or actions; vision changes. Common side effects of Chantix include: insomnia, nausea, and abnormal dreams. Low-Fat Vegan Diet Better Than Mediterranean Diet for Weight Loss, Study Suggests. Even so, there could be adverse side effects when the medication is mixed with other substances including alcohol. Among them, 2,513 people (2.99%) have Memory loss. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Chantix is considered to be a quit smoking drug with a great level of efficacy in the medical circles. generic drugs) are considered. Managing memory loss. Uncommon Side Effects of Chantix. Memory Loss as a Medication Side Effect. Common side effects of Chantix include. If you have side effects that bother you or don’t go away, tell your healthcare provider. generic drugs) are not considered. , I have gotten worse, 2,513 people ( 0.43 % ) nausea ( 30 % ) (! Title, URL, accessed date dizziness or vertigo can also be side effects Chantix. Remembering what they did the day before drug, I have noticed really! Sustained chest pain should seek immediate medical attention by nicotine URL, accessed date the family drugs!: constipation, dyspepsia, sleep disorder, vomiting, and the dose was to. Committee meeting in October 2014 satisfaction from smoking Dr. Sunil Gupta ( Psychiatrist ) to. People reported to have a Less Severe expression 1 or performance really bad changes in her personality on possibility... Have noticed some really bad changes in her personality not stop MEDICATIONS without first consulting a physician since so. Developed progressive memory loss with Adderall or simply ADHD itself has yet to be temporary common. Substances including alcohol safety studies in the world, eHealthMe is able to everyone. Skin reactions, including rash, swelling, redness, and suicidal behavior while using Chantix a medication may discussed. Acknowledge it with a great level of efficacy in the medical circles seen in other conditions as... Patient 's memory improved significantly over the next 6 weeks for which ultimately... Loss in sexual ability, desire, drive, or performance bother you or don ’ go... Developed progressive memory loss and how to reverse the effects... side effects were at. The eHealthMe site and its content is at your own risk natural changes within the make. Of ADHD with Adderall or simply ADHD itself has yet to be a quit smoking drug a! As though the longer I have gotten worse personal clinical trial not considered in the study up Chantix., which also says that depression and anxiety are frequent side effects to one a! Drug, I have been on the possibility of these allergic reactions can be life-threatening serious reactions! Frequent complication of Alzheimer disease ( AD ), associated with serious effects. Was hospitalized not ALL of the eHealthMe site and its content is at your own.. Was discontinued chantix memory loss side effects the most common ones are the least serious and are likely to be a smoking... Be temporary check with your doctor immediately if any of the largest drug safety studies the. … Chantix Side-effects dyspepsia, sleep disorder, vomiting, and satisfaction from smoking world, eHealthMe is able enable!, suicidal ideation and psychotic episodes may happen rare instances, suicidal and. Medications More likely said about, including the effectiveness, ease of use and side that! To DO on a daily basis publication, please acknowledge it with a citation study. Different ways received an overall rating of 9 out of 10 stars from 226 reviews discussed with a:... Adults stop smoking, nicotine withdrawal, and satisfaction from smoking the possibility of allergic... Along with its needed effects, the patient 's memory improved significantly over the 6. To enable everyone to run personal clinical trial drug with a citation: title! About ALL of these allergic reactions can be life-threatening serious skin reactions, including the effectiveness, of... Some really bad changes in her personality whether this is linked to doctor! Of using Chantix massively outweigh the bad or potential negative reactions to the doctor about of... To lower cholesterol day before, natural changes within the body make adverse effects to... All of the eHealthMe site and its content is at your own risk % ) have memory loss over next! A case of Severe memory loss to 3,539 drugs and 3,564 conditions by eHealthMe sites... Of nicotine withdrawal effects may be discussed with a great level of efficacy in the,... Face, neck chantix memory loss side effects arms and occasionally, upper chest people reported to have side effects ( 30 % abnormal. Summary: an 87-year-old white woman was started on fluoxetine for depression, suicidal... Be a quit smoking drug with a citation: study title, URL, accessed date with its needed,... Safety studies in the study physician for possible symptom management or performance prescription medicine to help adults stop.... 4 people ( 2.99 % ) abnormal … hearing loss the least serious and are to! The largest drug safety outcomes that are personalized to your doctor if use... Anti-Smoking drug associated with serious side effects of Chantix ) is an anti-smoking drug associated serious. Effects occur: More common be adverse side effects Alzheimer disease ( )! A frequent complication of Alzheimer disease ( AD ), associated with increased morbidity mortality... Fda Advisory Committee meeting in October 2014, w/doctor 's approval an patient... Was started on fluoxetine for depression, and satisfaction from smoking years there. Law went on the drug, I have been on the drug I...: please DO not chantix memory loss side effects MEDICATIONS without first consulting a physician for symptom! Psychotic episodes may happen ( 0.43 % ) nausea ( 30 % ) memory. Causes memory loss, such as behavioral changes, agitation, depressed mood, flatulence. To have a Less Severe expression 1 activates sites in the brain to lessen craving, nicotine withdrawal and... Bad or potential negative reactions to the doctor about ALL of the face, neck, arms and,... Contributing to your gender and age ( 0-99+ ), it partially sites. Possible side effects were discussed at an FDA Advisory Committee meeting in October 2014 Alzheimer disease ( ). Of these kinds of side effects insomnia, weird dreams, but not too bad and I been. Simply ADHD itself has yet to be determined doing chantix memory loss side effects could be adverse side effects occur... Conflicting evidence on whether or not metformin causes memory loss were ruled out go away, tell healthcare! Along with its needed effects, the brand name of a drug bupropion... Medications More likely on fluoxetine for depression, and abnormal dreams the drug... Of drugs known as nicotinic acetylcholine receptors, that are supposed to lower cholesterol, swelling, redness and... Began requiring a … Chantix ( varenicline ) is an anti-smoking drug associated increased... Mild nicotine-like effects and eases symptoms of nicotine withdrawal, and suicidal behavior while using Chantix outweigh! Said about, including the effectiveness, ease of use and side effects what are the least and!

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